Kathy Griffin knows how to derail an interview. On ‘Piers Morgan Tonight,’ Griffin threw Piers Morgan for a loop by alternately flirting with, then insulting him.

First, Griffin rose slowly from her chair and slid across Morgan’s desk to deliver a tender kiss on both cheeks.

“Oh my God! What’s going on?” cried Morgan. “You’re a bit of a brazen hussy, aren’t you?”

“Yes,” replied Griffin. “I’ll be over the table in two seconds. You have no idea. I’m just getting warmed up. Let me stretch.”

But Griffin quickly went from hot to cold and made fun of Morgan for “thinking he’s famous.”

“This is really awkward,” Morgan complained. “An empty chair would be an improvement.”

[Piers Morgan Tonight]